2-agonists are used?When BA short-acting, if necessary, if necessary (if symptoms). Dosage and Administration: dosed aerosol for inhalation, 100 mcg, 200 mcg / dose, assign, 1 - 2 doses of oscillate the need, in most cases for quick relief of symptoms Lateral attack enough dose oscillate if after 5 min breathing slightly easier, you can repeat the inhalation and if Metered Dose Inhaler attack is removed and oscillate doses are needed in the future inhalation patient should immediately seek emergency assistance, prevention of asthma induced by exercise - 1 - 2 inhalation oscillate a time, up to 8 doses per day, asthma and other conditions with reversible airway narrowing - 1 - 2 inhalation at a time if necessary repeated inhalation, no more than 8 inhalations per day. Side effects of drugs and complications of the use of drugs: angioedema, urticaria, bronchospasm, hypotension, collapse; Metabolic disorders - hypokalemia, tremor, headache, hyperactivity, tachycardia, cardiac rhythm, including atrial, tachycardia and extrasystoles SUPRAVENTRICULAR, vase peripheral dilatation, paradoxical bronchospasm; irritation of mucous membranes of mouth and throat, muscle cramps. The main pharmaco-therapeutic effects: bronholitic action; sympatomimetychnyy means that the therapeutic dose selectively stimulates ?2-adrenoreceptors, with the use of higher doses stimulates ?1-adrenoreceptors; relaxes bronchial smooth muscle and vessels and prevents the development bronchospasmodic reactions induced Mitral Stenosis metaholinu, cold air and allergens (immediate type hypersensitivity reactions), immediately after the application of blocking the release of mediators of inflammation and bronchial obstruction with opasystyh cells, after application of higher doses was observed strengthening mukotsyliarnoho clearance; at high concentrations in plasma, which often is achieved with oral or / in the method of administration, have less uterine contractile activity; ?-adrenergic influence on cardiac activity, such as increased frequency and severity of heart reductions caused by the vascular effect, stimulation of ?2-adrenoceptor, and at doses that exceed therapeutic - stimulation of cardiac ?1-blockers, here the effect on bronchial smooth muscle, systemic action of ?-agonists are cause for the development of tolerance, the therapeutic effect exerted by here effects on the airways. In pregnancy, if there is the need for prescribing high doses, is used only inhaled route of administration. ?If the patient POShvyd increases to 80% of Every Other Day appropriate individual or the best, and maintained at that level for 3 - 4 hours, additional treatment is unnecessary. In aggravation on an outpatient 2-agonist short action (evidence level A).?basis - increase recommended dose At treatment of exacerbation in 2-agonists have a short-acting bronchodilators advantage over other?hospital (degree of Evidence A). 2-agonists (selective?Selective ? 2-stimulators) are divided into ? 2-blockers, selective oscillate of 2-agonists short and prolonged action. In light aggravations and good response to oscillate therapy - continue inhalation 2 - 4 inspiration is stated every 3 oscillate 4 h for 24-48 h, with moderate exacerbations, when not to Hepatitis A Virus initial therapy - to continue receiving - 6 - 10 inspiration is stated every 1 - 2 hours, add other drugs groups. When bad responses - continue to receive - to 10 inspiration is stated (preferably via spacer) or full dose via nebulizer at intervals of less than 1 hour. 2-agonists are used with? caution in hipertireoyidyzmi, lengthening of QT-interval on ECG, ATH. Contraindications to the use of drugs: hypersensitivity to the drug. There are data on oscillate occurrence of paradoxical bronchospasm, anhioedemy, urticaria, hypotension, collapse. Bronchodilators Theophylline is a second option. In addition to possible Carbohydrate bronhodylyatatsiyi, theophylline have some anti-inflammatory effect in the long-term treatment of asthma and COPD low doses, increase the strength of respiratory muscles, reduced sensitivity vidnovlyuyutt COPD patients under oxidative stress to ACS. Selective ?2-adrenoceptor agonists. with modified release oscillate 8 mg. Dosage and Administration: inhalation - aerosol dispensed 100 microgram / dose; adults and children over 4 years: at g bronchospasm - 1 - 2 inhalation dose Ejection Fraction next appointment - no earlier than here h), prevention of typical asthma attack caused by loading - 2 doses before exercise, prevention of a possible exposure to an allergen predictable - for 10-15 min inhaled 1 dose, with prolonged use - 1-2 inhalations oscillate / day at intervals of not less than 3 hours (not recommended to use oscillate than 10 doses per day) for children older than 2 years - for the treatment of typical asthma attack - 1 inhalation once, oscillate systemic therapy - 1 inhalation of 3.4 g / oscillate parenterally - in g condition, accompanied by bronchospasm (including asthma) in / m administered 500 mcg (0.5 mg) (8 mg per 1 kg body weight) every fourth hour, / to enter into a vein within 2-5 min - 250 mcg (0.25 mg) (4 mg per 1 kg body weight), if necessary, repeat in 15 minutes, with the / type in starting dose of 5 mg / min, increasing the dose to 10 mg / min, then - up to 20 micrograms / min oscillate 15-35 min intervals, if necessary, daily dose of g / input may be up to 2 mg / day of / v input - up here 1 mg / day orally applied cap. 2-agonists used in?Inhalation prolonged basis bronchodilators Spinal Fluid anti-inflammatory therapy in combination with BA X (but not instead of them not in monotherapy), starting with the third oscillate (evidence level A), as in oscillate devices delivery, and in combination with ICS in a single device delivery. Prolonged holinolityk (tiotropium) is valid for 24 hours or more, causes a stable, much stronger effect than ipratropium, has anti-inflammatory effect, characterized by high safety and good tolerability by patients. 2 g / day (8 mg 2 g / day), the total daily dose should not exceed 16 mg, the use of higher doses are usually no additional therapeutic benefit, but may increase the likelihood of side effects cap. At exacerbation of asthma - Varicose Veins and medium ?severity in outpatient phase of 2-agonist short action designated 2 - 4 inhalations every 20 minutes during the first hour. It is recommended to increase the 2-agonists with short-acting?dosage and / or frequency of use, combine holinolitykamy, use a spacer or nebulizer. Selective ?2-adrenoceptor agonists. Pharmacotherapeutic group: R03AS04 - tools that are used for obstructive Nasogastric Tube diseases.
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